Type IV Collagen - an overview | ScienceDirect Topics
Type IV collagen is a major constituent of basement membranes. The type IV collagen family of proteins comprises six isomeric chains, designated α1(IV) to α6(IV).
Collagen IV in Normal Skin and in Pathological Processes
Type IV collagen is a type of collagen found primarily in the skin within the basement membrane zone. The type IV collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers are thus link head-to-head, rather than in a parallel fashion.
Collagen: What It Is, Types, Function & Benefits - Cleveland Clinic
Type I is densely packed and used to provide structure to your skin, bones, tendons and ligaments. Type II. This type is found in elastic cartilage, which provides joint support. Type III. This type is found in muscles, arteries and organs. Type IV. …
Mammalian Collagen IV - PMC
Type IV collagen is a unique member of the large collagen superfamily which in vertebrates comprise 28 different types (Myllyharju and Kivirikko, 2004; Veit et al., 2006). Unlike most collagens, type IV collagen occurs only in the basement membranes (BMs) and comprises up to six genetically distinct α-chains designated α1(IV) to α6(IV).
A Review of the Effects of Collagen Treatment in Clinical Studies
Collagen type IV is the predominant collagen of the basement membrane forming the backbone of the basement membrane. Mutations in collagen type IV can cause chronic kidney disease, Alport’s syndrome [ 19 ].
Collagen Type 4 - an overview | ScienceDirect Topics
Type IV collagen is the major collagenous component of basement membranes (Timpl, 1989), which form a three-dimensional scaffold to which different cells, for example vascular cells, are attached (Marshall et al., 1993).
Type IV collagen - ScienceDirect
2024年1月1日 · Type IV collagen is the main collagen component of the basement membrane. It is a network-forming collagen that underlies epithelial and endothelial cells and functions as a barrier between tissue compartments. Type IV collagen has many binding partners and is the backbone of the basement membrane.
Type IV Collagens and Basement Membrane Diseases: Cell …
Type IV collagens are a major component of all basement membranes. They evolved along with the earliest multicellular organisms and have been integrated into diverse fundamental biological processes as time and evolution shaped the animal kingdom.
Basement Membrane Type IV Collagen and Laminin: An Overview …
2017年2月10日 · All basement membranes contain type IV collagen (Col IV), laminin, nidogen, and perlecan. Col IV and laminin self-assemble into two independent supramolecular networks that are linked to nidogen and perlecan to form a morphological discernable basement membrane/basal lamina.
Collagen: quantification, biomechanics and role of minor ... - Nature
2020年7月20日 · The major isoform of collagen type V is α1 2 α2, which co-assembles with collagen type I 180, where type I fibrils are copolymerized on a template of collagen type V 181.
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