Urine LAM is a promising TB diagnostic biomarker for use in a POC TB test, with the potential to reach adult and pediatric patients regardless of HIV status or site of infection.

Urine is increasingly being investigated as a convenient clinical sample for the identification of mycobacterial products for the diagnosis of tuberculosis. The available literature on mycobacterial lipoarabinomannan (LAM) and urine mycobacterial DNA is reviewed.

2019年11月4日 · WHO has updated its guidance for the use of lateral flow urine lipoarabinomannan assay (LAM) in the diagnosis of tuberculosis (TB). Following new evidence, WHO now recommends more broader use of urinary LAM assays for diagnosis of …

LAM antigen is released from metabolically active or degrading bacterial cells during active TB infection and passes via the kidneys into the urine. A lateral flow assay is available for the detection of LAM antigen in urine.

2019年10月28日 · The WHO Global TB Programme convened a Guideline Development Group meeting in 2015 to review the evidence for the use of lateral flow urine lipoarabinomannan assay (LF-LAM). The current document provides the background, justification and objectives for the revision of WHO policy on LF-LAM.

In this article, we review and explain how urine-LAM assays should be understood as diagnostics for disseminated TB in HIV-positive patients with advanced immunodeficiency, in whom haematogenous TB dissemination to the kidneys serves as the primary mechanism by which LAM enters the urine.

The urine LF-LAM is an immunocapture assay based on the detection of the mycobacterial LAM antigen in urine; it is a potential point-of-care test for certain populations being evaluated for TB.

2021年3月19日 · Lawn SD, Gupta-Wright A. Detection of lipoarabinomannan (LAM) in urine is indicative of disseminated TB with renal involvement in patients living with HIV and advanced immunodeficiency: evidence and implications.

2019年12月31日 · Lipoarabinomannan (LAM) is the only WHO-endorsed TB biomarker that can be detected in urine, an easily collected sample. This status update discusses the characteristics of LAM as a biomarker, describes the performance of first-generation urine LAM tests and reasons for slow uptake, and presents considerations for developing the next generation ...

BENEFITS OF URINE LAM TESTING • Saves lives!—the LAM test is the only TB test shown to reduce deaths.12 A randomized clinical trial of 2,000 hospitalized people with HIV in South Africa, Tanzania, Zambia, and Zimbabwe showed that using LAM was associated with a four percent reduction in the number of people who died in the first eight