Multifaceted roles of GSK-3 and Wnt/β-catenin in ... - Nature
2013年6月19日 · In this review, we will discuss the roles that GSK-3 plays in hematopoiesis and leukemogenesis as how this pivotal kinase can interact with multiple signaling pathways such …
GSK3: a multifaceted kinase in Wnt signaling - PMC - PubMed …
Recent advances indicate that GSK3 also plays a positive role in Wnt signal transduction by phosphorylating the Wnt receptors low density lipoprotein receptor-related protein (LRP5/6) …
Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct ...
2017年1月17日 · Here, we show that upon exposure to glycogen synthase kinase 3 (GSK3) inhibitors alone, the expression of definitive endoderm specific genes GATA4, FOXA2, and …
GSK3: a multifaceted kinase in Wnt signaling - PubMed
The recent demonstration of GSK3 involvement in Wnt receptor phosphorylation illustrates the multifaceted roles that GSK3 plays in Wnt-beta-catenin signaling. In this review, we will …
Glycogen synthase kinase-3 (GSK3): regulation, actions, and …
2021年11月27日 · Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
Role of GSK-3β in Regulation of Canonical Wnt/β-catenin ... - PubMed
2017年8月9日 · GSK-3β, a serine threonine kinase and a negative regulator of the oncogenic Wnt/β-catenin signaling pathway, plays a critical role in the regulation of oncogenesis.
In vivo regulation of glycogen synthase kinase 3β activity in …
2017年8月17日 · Glycogen synthase kinase 3β (GSK3β) is a multifunctional protein kinase that targets Ser/Thr residues with a priming phosphorylation at the fourth amino acid on the C …
GSK3: a multifaceted kinase in Wnt signaling - Cell Press
2009年11月2日 · The recent demonstration of GSK3 involvement in Wnt receptor phosphorylation illustrates the multifaceted roles that GSK3 plays in Wnt-β-catenin signaling.
Glycogen synthase kinase 3 in Wnt signaling pathway and cancer
2015年11月24日 · Indeed, aberrant Wnt signaling is a hallmark of the majority of colorectal cancers, and GSK-3β is a central player in the canonical Wnt pathway, which operates …
Here, we report that Wnt signaling triggers the sequestration of GSK3 from the cytosol into multivesicular bodies (MVBs), so that this enzyme becomes separated from its many cytosolic …
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