Multifaceted role of mTOR (mammalian target of rapamycin) …
2023年10月2日 · Here, we provide the detailed structure of mTOR, its complexes, and the comprehensive role of upstream regulators, as well as downstream effectors of mTOR …
mTOR Signaling in Growth, Metabolism, and Disease - PMC
The mechanistic Target of Rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs including nutrients and growth factors. Extensive research over the …
mTOR signaling at a glance - PMC - PubMed Central (PMC)
Here, we highlight and summarize the current understanding of how mTOR nucleates distinct multi-protein complexes, how intra- and extracellular signals are processed by the mTOR …
mTOR signaling and its roles in normal and abnormal brain …
In the central nervous system, the mTOR signaling cascade is activated by nutrients, neurotrophic factors, and neurotransmitters that enhances protein (and possibly lipid) synthesis and …
mTOR signaling pathway and mTOR inhibitors in cancer: progress …
2020年3月10日 · Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown …
mTOR Signaling in Growth, Metabolism, and Disease
2017年3月9日 · The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors.
What is the mTOR Signaling Pathway? - News-Medical.net
2020年3月9日 · In mammalian cells, one of the most vital pathways for cellular growth and metabolism is the mTOR signaling pathway. Image Credits: ibreakstock / Shutterstock.com.
mTOR: from growth signal integration to cancer, diabetes and …
2010年12月15日 · Advances in our understanding of the regulation and functions of mammalian TOR (mTOR) are revealing its involvement in diabetes, cancer and ageing.
Where is mTOR and what is it doing there? - PubMed
2013年11月25日 · In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different …
mTOR signaling at a glance - The Company of Biologists
2009年10月15日 · Discoveries that have been made over the last decade show that the mTOR pathway is activated during various cellular processes (e.g. tumor formation and angiogenesis, …
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