Arsphenamine - an overview | ScienceDirect Topics
Arsphenamine is a chemical agent that was used to treat patients with syphilis, along with other diseases, without posing significant danger to the patient. AI generated definition based on: Biochemical Engineering and Biotechnology, 2007
Arsphenamine - an overview | ScienceDirect Topics
Arsoles, stiboles, and bismoles. Viktor Milata, in Advances in Heterocyclic Chemistry, 2020. 1 Introduction. Perhaps the best-known substance containing a higher pnictogen (or pentel) atom is Ehrlich's Salvarsan (compound 606, arsphenamine) containing arsenic (1911P1), from 1907; the antisyphilitic activity of this was discovered by S. Hata in 1909.
Arsphenamine - an overview | ScienceDirect Topics
An organoarsenic compound, Erlich's arsphenamine (Salvarsan, 606), so named because it was the 606th preparation of the compound, was used to treat neurosyphilis patients beginning in 1912 following successful experiments with rabbits [1]. Although generally considered effective, patients with tabetic or paretic neurosyphilis proved resistant.
Arsphenamine - an overview | ScienceDirect Topics
The first modern chemotherapeutic agent was arsphenamine, which was used to treat syphilis and trypanosomiasis in the early 20th century. It was developed in Paul Ehrlich's laboratory and although arsphenamine was not an anti-cancer chemotherapeutic agent, its development and use did parallel that of more conventional anti-cancer drugs.
Arsphenamine - an overview | ScienceDirect Topics
Arsphenamine (salvarsan) is a mixture of a trivalent triphenyl and a pentavalent pentaphenyl organoarsenic compounds. Neosalvarsan (pharmaceutical historically used for treating syphilis). Thiacetarsamide sodium (caparsolate, adulticide used in the treatment of heartworm).
Arsphenamine - an overview | ScienceDirect Topics
2015年12月31日 · An organoarsenic compound, Erlich's arsphenamine (Salvarsan, 606), so named because it was the 606th preparation of the compound, was used to treat neurosyphilis patients beginning in 1912 following successful experiments with rabbits [1]. Although generally considered effective, patients with tabetic or paretic neurosyphilis proved resistant.
Arsphenamine - an overview | ScienceDirect Topics
In 1909, Ehrlich’s laboratory discovered arsphenamine (Salvarsan), an arsenical compound and the first effective treatment for syphilis. 2,3 At that time, syphilis was widespread in Europe and mercury salts were the only known treatment. Arsphenamine was more effective than mercury salts, with a much reduced toxicity, although its safety and ...
Infections caused by resistant organisms: Could organic arsenic ...
2017年7月1日 · They ushered in the age of targeted chemotherapy in 1910 with the discovery of the anti-syphilitic organic arsenic agent, arsphenamine or Salvarsan (also known as 606). It was the clinical compound of choice for treating syphilis until penicillin and other antibiotics were introduced clinically in the 1940s.
THE CHEMISTRY OF NEOARSPHENAMINE AND ITS RELATION TO …
This work has been undertaken mainly with the object of determining whether sodium formaldehyde sulfoxylate is attached to one or both amino groups of the arsphenamine molecule according to the following formulas: As-As As--As This is an important chemotherapeutic problem, since recently Schamberg, Kolmer, and Raiziss (1) demonstrated that not ...
Neoarsphenamine - an overview | ScienceDirect Topics
Gradually, chemical agents were identified and used for treating patients. Toxic compounds, such as mercury, were used to treat syphilis for eighteen centuries. Even arsenic compounds were used to cure many diseases without great danger to the patient. Arsphenamine and neoarsphenamine were also used to treat patients with syphilis ...