Interleukin 1 beta - Wikipedia
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.
Understanding the mechanism of IL-1β secretion - PMC
Qu Y., Franchi L., Nunez G., Dubyak G.R. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages.
Interleukin 1beta - an overview | ScienceDirect Topics
Interleukin-1(IL-1) is a cytokine which governs inflammatory responses by binding IL-1 α and β agonist with its receptor IL-1R (Vigers et al., 1997). IL-1β is synthesized by inflamasome-mediated caspase action ( Bent et al., 2018 ) and enhances the immune reaction ( Dinarello, 2014 ).
Interleukin-1 family - Wikipedia
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.
Overview of the IL-1 family in innate inflammation and acquired ...
The interleukin-1 (IL-1) family of cytokines and receptors is unique in immunology because the IL-1 family and Toll-like receptor (TLR) families share similar functions. More than any other cytokine family, the IL-1 family is primarily associated ...
Pro-Inflammatory Cytokines Overview - Thermo Fisher Scientific
IL-1 is subdivided in IL-1α and IL-1β. IL-1β is potent pro-inflammatory cytokine, induced mainly by lymphocytes, macrophages, and monocytes in response to microbial molecules. Upon viral infection, the pattern recognition receptors (PPR) and toll-like receptors (TLRs) are expressed which in turn lead to enhanced expression of IL-1β.
Role of interleukin-1β during pain and inflammation - PMC
Interleukin-1 α and β are prototypic proinflammatory cytokines that exert pleiotrophic effects on a variety of cells and play key roles in acute and chronic inflammatory and autoimmune disorders. There are two IL-1 receptors, IL-1 type 1 receptor (IL-1RI) and IL-1 type 2 receptor (IL-1 RII). IL-1α and IL-1β signal through IL-1RI.
The IL-1 family: regulators of immunity - Nature
2010年1月18日 · This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, their regulation...
Structural insights into the assembly and activation of IL-1β
2010年8月29日 · Interleukin 1β (IL-1β) is a key orchestrator of inflammation and host defense that exerts its effects through IL-1 receptor type I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).
Interleukin-1 in the pathogenesis and treatment of …
2011年4月7日 · Since Toll-IL-1-receptor domains are functional for both receptor families, responses to the IL-1 family are fundamental to innate immunity. Of the 11 members of the IL-1 family, IL-1β has emerged as a therapeutic target for an expanding number of systemic and local inflammatory conditions called autoinflammatory diseases.