Irinotecan - Wikipedia
Irinotecan is a topoisomerase inhibitor [9] —it blocks the topoisomerase I enzyme, resulting in DNA damage and cell death. [8] Irinotecan was approved for medical use in the United States in 1996. [8] It is on the World Health Organization's List of Essential Medicines. [10]
Irinotecan (intravenous route) - Mayo Clinic
2024年10月1日 · Irinotecan can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are needed for proper blood clotting.
Irinotecan Hydrochloride - NCI - National Cancer Institute
Irinotecan hydrochloride is a type of chemotherapy drug called a topoisomerase I inhibitor. It causes breaks that cannot be repaired in the DNA of cells. This stops the growth of cancer cells and other rapidly dividing cells and causes them to die.
Irinotecan Uses, Side Effects & Warnings - Drugs.com
2024年4月3日 · Irinotecan is used to treat cancers of the colon and rectum. It is usually given with other cancer medicines. Irinotecan may also be used for purposes not listed in this medication guide.
Monitor patients with diarrhea and give fluid and electrolytes as needed. Institute antibiotic therapy if patients develop ileus, fever, or severe neutropenia. Interrupt CAMPTOSAR and reduce...
Irinotecan: Uses, Interactions, Mechanism of Action - DrugBank …
Upon administration, irinotecan is converted into its active metabolite, SN-38, by carboxylesterase in the liver and gastrointestinal tract. 3 Irinotecan and SN-38 both inhibit DNA topoisomerase I, acting on the S and G2 phases of the cell cycle. 4,7 Irinotecan and SN-38 bind to the topoisomerase I-DNA complex and prevent the religation of ...
Irinotecan - StatPearls - NCBI Bookshelf
2023年7月21日 · Irinotecan is a medication used to manage and treat a variety of solid tumors. It is in the DNA topoisomerase I inhibitor class of drugs. Also known as CPT-11, irinotecan is used adjunctively with other therapeutic agents against colorectal cancer as a first- …
Irinotecan: Package Insert / Prescribing Info - Drugs.com
2024年7月3日 · Irinotecan hydrochloride injection is a topoisomerase inhibitor indicated for: First-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic carcinoma of the colon or rectum. (1)
Irinotecan Injection: MedlinePlus Drug Information
Irinotecan is used alone or in combination with other medications to treat colon or rectal cancer (cancer that begins in the large intestine). Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells. How should this medicine be used?
DailyMed - IRINOTECAN HYDROCHLORIDE 100 MG/5 ML- irinotecan …
2020年9月7日 · Irinotecan hydrochloride injection, USP is an antineoplastic agent of the topoisomerase I inhibitor class. Irinotecan hydrochloride injection, USP is supplied as a sterile, pale yellow, clear, aqueous solution.