Myc - Wikipedia
Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs).
MYC Gene - GeneCards | MYC Protein | MYC Antibody
2024年10月2日 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Prolactin Signaling and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
MYC: a multipurpose oncogene with prognostic and therapeutic ...
2021年8月9日 · MYC (mostly referred to as c-Myc) is a super-transcription factor encoded by the MYC gene located at chromosome 8 q24.21 [1]. The MYC oncoproteins (C-myc, N-myc, and L-myc) controls the transcription of nearly 15% of expressed genes [2].
MYC function and regulation in physiological perspective
2023年10月23日 · MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier that regulates almost every physiological process in a cell including cell cycle, proliferation, metabolism, differentiation, and apoptosis. MYC interacts with several cofactors, chromatin modifiers, and regulators to direct gene expression.
The N-myc Oncogene: Maximizing its Targets, Regulation, and …
2014年6月1日 · Tight control of N-myc expression is an essential cellular mechanism for modulating N-myc function. There are a number of mechanisms for N-myc regulation; one is through control of N-myc turnover by protein degradation. N-myc protein turnover is cell-cycle dependent with N-myc degradation occurring during mitosis.
UniProt
POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. 1 publication
MYC gene information - The Human Protein Atlas
Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).
Targeting MYC at the intersection between cancer metabolism …
In this review, we enumerate the recent studies that characterize the targets and partners of MYC involved in cancer metabolism and immunology. Further, we discuss current evidence of the overlap between cellular functions governed by MYC …
Molecular Mechanisms of MYCN Dysregulation in Cancers
2021年2月2日 · MYC proteins affect transcription of a large number of genes and thus regulate fundamental cellular processes, including proliferation, metabolism, apoptosis, differentiation, and immune surveillance (17 – 21). Figure 1 Models of transcriptional regulation of target genes by MYC proteins. (A) Schematic diagram of N-MYC protein structure.
MYC protein helps cancer to take its vitamins - Nature
2023年12月12日 · Nature - High levels of MYC protein boosts vitamin B5 uptake in cancer cells. Identifying nutrient dependencies of cancer cells is crucial for developing new therapies.