PARP inhibitors are a call of drugs that are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP), which plays a role in repairing DNA in damaged cells. …

2024年4月3日 · PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) …

2023年4月14日 · A PARP inhibitor stops cancer cells being repaired which causes the cells to die and reduces tumor growth. How they work DNA damage and mutation occurs naturally and …

2020年9月9日 · PARP inhibitors (PARPi) were the first approved cancer drugs that specifically targeted the DNA damage response in BRCA1/2 mutated breast and ovarian cancers.

2021年3月15日 · PARP inhibitors block the action of the PARP enzymes: PARP-1, PARP-2, and PARP-3. These all help repair damaged DNA in cells. PARP inhibitors can keep cancer cells …

2022年1月12日 · PARP inhibitors are drugs that block the DNA-repairing mechanism of PARP. By preventing PARP from repairing the damaged DNA within cancer cells, PARP inhibitors can …

Beyond PARP inhibitors, there is now a large armamentarium of potent and relatively selective inhibitors in clinical trial testing against key targets involved in the DDR, including ATR, ATM, …

2024年9月24日 · PARP inhibitors are a type of targeted cancer drug. They are a treatment for several types of cancer including ovarian, breast and prostate cancer. They are also in trials …

PARP inhibitors act through synthetic lethality with mutations in DNA repair genes and were approved for the treatment of BRCA mutated ovarian and breast cancer. PARP inhibitors …

PARP inhibitors have emerged as a promising class of anticancer agents approved for the treatment of ovarian, breast, prostate, and pancreatic cancer. These inhibitors target PARP …