A stem-loop occurs when two regions of the same nucleic acid strand, usually complementary in nucleotide sequence, base-pair to form a double helix that ends in a loop of unpaired nucleotides. Stem-loops are most commonly found in RNA, and are a key building block of many RNA secondary structures .

2024年5月15日 · What is a stem-loop (hairpin loop)? A Stem-loop can be defined as a hairpin-like pattern formed because of the intramolecular base pairing of the nucleotide sequence (especially in palindromic sequence) within the same molecule.

2012年8月28日 · The stem–loop structures, also called hairpins, play an important role in the tertiary folding of RNA molecules. They also serve as critical sites for the interaction with other nucleic acids and proteins.

A stem-loop is a specific structural motif in RNA characterized by a double-stranded 'stem' formed by complementary base pairing, followed by a single-stranded 'loop' where the sequence is unpaired.

The structure is also known as a stem-loop structure. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions, base-pair to form a double helix that ends in an unpaired loop.

Stem-loops, also known as hairpin loops, are secondary structures formed in single-stranded RNA molecules. They consist of a double-stranded stem region and a single-stranded loop region, creating a characteristic hairpin-like shape that is essential for various biological functions.

Here we present a systematic analysis of SLS distribution in prokaryotic genomes. Sequences able to fold into stem-loop structures featuring relatively large (12 or more bp) stems have been searched and analyzed in 40 wholly-sequenced bacterial chromosomes.

A stem-loop in the context of Neuroscience refers to a partially self-complementary sequence that is designed to reverse the biogenesis of microRNA. It is used in stem-loop reverse transcription to copy the mature microRNA sequence and enhance the specificity of the process.

2002年6月1日 · Here, I review new diagnostic approaches based on the formation of stem-loop DNA oligonucleotides: molecular beacon methodology, suppression PCR approaches and the use of hairpin probes in DNA microarrays. The advantages of these techniques over existing ones for sequence-specific DNA detection, amplification and manipulation are discussed.

2013年1月18日 · The stem-loop binding protein (SLBP) specifically recognizes the SL to regulate histone mRNA metabolism, and the 3′-5′ exonuclease 3′hExo trims its 3′-end after processing. We report the crystal structure of a ternary complex of human SLBP RNA binding domain, human 3′hExo, and a 26-nucleotide SL RNA.