Peck, G. L. et al. Isotretinoin versus placebo in the treatment of cystic acne: A randomized double-blind study. Journal of the American Academy of Dermatology 6, 735–745 (1982). Goldstein, J. A. et al. Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion. J Am Acad Dermatol 6, 760–765 (1982).

2022年8月30日 · However, patients receiving the tretinoin polymer gel reported less peeling and dryness, even if the overall level of side effects was similar between the two groups. 15. Tretinoin nanogel vs. Tretinoin gel. Scientists continue to develop new vehicles for retinoids in order to increase efficacy and decrease side effects.

A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. British Journal of Dermatology 165, 177–183 (2011). Lucky, A. W. & Sugarman, J. Comparison of micronized tretinoin gel 0.05% and tretinoin gel microsphere 0.1% in young adolescents with acne: a post hoc analysis of efficacy and tolerability data.

2022年4月20日 · Isotretinoin Does Not Always Achieve a Long-term Result, and 14.6 – 52% of Patients Relapse The Essential Info Isotretinoin, often known by its original brand name, Accutane®, is an oral prescription medication that dermatologists sometimes prescribe to people with severe, scarring acne that does not respond to other treatments. It is effective, and can …

The following side effects are expected to occur during treatment with isotretinoin. Contact your doctor if these symptoms are severe and/or do not go away on stopping treatment: How Common (based on clinical studies) Sore, cracked, or red lips Up to 100% of all users Dryness of skin, mouth, nose, or eyes Up to 100% …

2024年11月20日 · However, despite warnings to women not to get pregnant while using isotretinoin, studies published in Canada, the Netherlands, and the UK report a range of 11-24 per 1000 women getting pregnant while on isotretinoin. 6-8 This is lower than the pregnancy rate in the general population of these countries which stands at approximately 50 per 1000 women, …

Ioannides D, Rigopoulos D, Katsambas A. Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial. British Journal of Dermatology 147, 523–527 (2002).

Pariser, D. et al. Tretinoin gel microsphere pump 0.04% plus 5% benzoyl peroxide wash for treatment of acne vulgaris: morning/morning regimen is as effective and safe as morning/evening regimen. J Drugs Dermatol 9, 805–813 (2010).

2023年10月10日 · Tretinoin. Studies have shown that when patients apply tretinoin nightly for a period of 12 weeks, it results in an average reduction of 17 – 71% of non-inflammatory lesions, a 33 – 81% reduction of inflammatory lesions, and a 22 – …

A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials. Br J Dermatol 139 Suppl 52 , 48–56 (1998).