SOLVED:The alcohol dehydrogenase reaction, described in Figure 17.11 , interconverts ethyl alcohol and acetaldehyde and involves hydride transfer to and from NAD^ and NADH, respectively. Write a reasonable mechanism for the conversion of ethanol to acetaldehyde by alcohol dehydrogenase.

SOLVED:Ethanol Intoxication and Methanol Toxicity. The enzyme alcohol dehydrogenase was mentioned in this chapter because of its role in the final step of alcoholic fermentation. However, the enzyme also occurs commonly in aerobic organisms, including humans. The ability of the human body to catabolize the ethanol in alcoholic beverages depends on the presence of alcohol dehydrogenase in the liver. One effect of ethanol intoxication is a dramatic decrease in the NAD ^ concentration in liver cel

SOLVED:Ethanol Affects Blood Glucose Levels The consumption of alcohol (ethanol), especially after periods of strenuous activity or after not eating for several hours, results in a deficiency of glucose in the blood, a condition known as hypoglycemia. The first step in the metabolism of ethanol by the liver is oxidation to acetaldehyde, catalyzed by liver alcohol dehydrogenase: (EQUATION CANNOT COPY) Explain how this reaction inhibits the transformation of lactate to pyruvate. Why does this lead

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