Cortisol regulation involves the hypothalamus, pituitary gland, and adrenal glands. The hypothalamus releases corticotropin-releasing hormone (CRH), which signals the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH stimulates the adrenal glands to produce cortisol. Negative feedback loop maintains cortisol levels: rising levels inhibit CRH and ACTH release. Cortisol affects metabolism, immune response, and stress response. #cortisolconnection#cortisolregulation#cortisolhormon