etinoin is not toxic, harsh, or pore clogging. Tretinoin is a well established, safe, and effective acne treatment that has been in use as an acne treatment for over 50 years. Isopropyl myristate in tretinoin cream is not “pore clogging.” If the cream vehicle is not agreeable to you, talk to your dermatologist about other vehicle options (gel, lotion). Dryness, irritation, peeling, and an increase in acne spots are temporary side effects that resolve with ongoing use, or with switching to a diff